Why I Take C60 Oil: Benefits, Science, and Safety Explained

Q: What were some specific findings regarding C60 oil's effects on heart tissue in research studies?

Specific findings from research include: Liposoluble C60 inhibited neutrophil activity, including migration, phagocytosis, and TNF-α release, at the cellular level. In rats with DMBA-induced heart tissue damage, C60 treatment reduced oxidative stress markers (MDA) and inflammatory markers (COX-2, TNF-α), while increasing antioxidant enzymes (CAT, GSH) and markers related to cell survival (Caspase-3, p53, HO-1). In rats subjected to cardiac ischemia/reperfusion injury, both intratracheal and intravenous C60 exposure led to an expansion of myocardial infarction size. C60 exposure in rats altered the pharmacological responses of isolated coronary arteries, impacting relaxation and contraction depending on the route of administration and sex. In mice with atherosclerosis, systemic C60 treatment resulted in reduced endothelium-dependent and -independent vasorelaxation responses in aorta segments.

🛑 ⚠️ Update: I’ve Paused C60 Use After Reviewing the Science

After diving deep into the research with the help of NotebookLM, I’ve uncovered some serious concerns about how C60 behaves in individuals with cardiovascular injury — like me.

In animal models (rats and mice), C60 has been shown to:

Concept Art of a C60 Molecule being the future of health

Worsen heart injury after ischemia-reperfusion events (heart attack models)
Impair blood vessel relaxation, particularly in animals already prone to atherosclerosis
Act as a pro-oxidant in certain conditions (especially in the presence of light)
Show different effects based on delivery method (oral vs. inhaled vs. injected) and even sex of the animal

Even more complex: in zebrafish embryos, C60 acted as a harmful oxidant unless they were kept in the dark — and antioxidant levels in the body dramatically changed the outcome.

This isn’t to say C60 has no value. The original rat lifespan study still stands as fascinating — and there are personal reports of benefits (including mine). But the new evidence suggests C60 may interact very differently in bodies under cardiovascular stress.

🔴 That’s why I’ve chosen to stop using C60 for now. Until we understand more — especially how it behaves in humans with heart issues — I’m playing it safe.

🧪 What I’m Doing Next:

I’ll continue to track the science and update this article as new studies emerge.
If you’re healthy and still curious about C60, read the full post below — but know the risks aren’t fully understood yet.

If you have any history of heart problems, I encourage you to:
👉 Watch the deep dive video I commissioned
👉 Speak to a qualified health professional before considering C60.

Below is the article I wrote before this revelation. For people who do not have a heart condition, this may still be a useful supplement.

If you told me a few years ago that I’d be swallowing a molecule made of 60 carbon atoms shaped like a tiny football (or soccer ball, depending on your side of the world), I’d have raised an eyebrow. But here I am — regularly taking C60 oil, and genuinely feeling the difference.

So what exactly is this mysterious molecule, and why do I take it? (on balance).

⚫ What is C60?

C60, short for Carbon 60 or Buckminsterfullerene, is a molecule made up of 60 carbon atoms arranged in a spherical shape — like a tiny nano-cage. It was only discovered in 1985 and won the Nobel Prize in Chemistry in 1996. Yep, it’s legit science.

But beyond being a scientific curiosity, some early research shows that it may have serious potential as an antioxidant and mitochondrial protector.

🧪 The Study That Turned Heads

Back in 2012, a now-famous rat study made waves. Researchers gave one group of rats C60 dissolved in olive oil, and another group plain olive oil.

Before any of the lifespan results made headlines, the original 2012 study was actually designed to test toxicity, not longevity. Because C60 shares structural similarities with benzene — a well-known carcinogen — researchers wanted to find out how safe it really was when taken long-term. They weren’t expecting life extension; they were trying to see if it caused harm. What they found instead was surprising: not only was C60 non-toxic at the tested dose, it dramatically extended lifespan in rats.

Quote from the 2012 Study

C60 is a very promising material for various medical applications, but its toxicity is still a matter of debate. In this context, the aim of this work was to assess the in vivo toxicity of C60.

Baati et al. study was to evaluate the chronic toxicity of C60 dissolved in olive oil. – The results were surprising!

The results?

⚡ The C60 group lived nearly twice as long.
Median lifespan jumped from around 22 months to 42 months — a 90% increase.

Even more surprising: they stopped giving C60 at month 17 — and the benefits still continued. The final C60-treated rat lived until month 66, with a median lifespan of 42 months, compared to just 22 months in the control group.

Now, before you start picturing yourself as the next immortal monk, let’s be clear: this was a small animal study. It hasn’t been replicated in humans, and there’s still a lot we don’t know. But it’s compelling enough to keep my curiosity piqued — and my bottle of C60 close by.

🧬 Why It Makes Sense for My Stack

I follow a mostly carnivore-style diet and use red light therapy regularly. Here’s how C60 complements that lifestyle:

🛡 1. Antioxidant Power

C60 is an unusually potent antioxidant — it doesn’t just “donate an electron” like typical antioxidants, it can neutralize multiple free radicals without degrading. That’s huge if you’re trying to reduce oxidative stress without messing with your body’s natural hormesis.

❤️ 2. Cardiovascular Support

Some studies suggest C60 may help reduce triglycerides and stabilize blood pressure — both of which align well with the natural effects of a clean carnivore or keto lifestyle.

⚡ 3. Mitochondrial Boost

It may help improve mitochondrial efficiency, leading to more stable energy throughout the day — something I really notice on the days I take it.

🧠 4. Brain Fog Begone

Because it crosses the blood-brain barrier, it’s also thought to support cognitive clarity. Combined with red light therapy and a clean diet, this trifecta helps me feel focused, alert, and (dare I say) sharper than ever.

🔥 5. Inflammation Control

Even though my carnivore diet already keeps inflammation in check, C60 seems to give it an extra edge, especially after intense training or stressful days.

🥄 How I Take It

I take C60 in extra virgin olive oil, usually in the morning or with my first fatty meal. 2 – 5 ml, once per week. Some people prefer avocado or MCT oil versions — I just go with what feels right and fits my stack.

Important note: quality matters. There’s a lot of junk out there. I only use C60 from trusted brands that follow lab-grade manufacturing and transparency standards. (I’m not here to sell you a brand — just a mindset: be picky.)

Where to Buy C60 (and What to Watch Out For)

Not all C60 products are created equal — and with the growing popularity of C60 oil, there’s no shortage of low-quality or even misleading brands entering the market. Since you’re putting something potentially powerful into your body, it’s worth knowing how to spot the good from the gimmicky.

⚠️ Potential Risks of Poor-Quality C60:

Impurities or solvents left over from cheap manufacturing
Low purity C60 (less than 99.9%)
Fake “black” oils made with charcoal or soot instead of actual C60
Non-dissolved C60 powder that won’t be bioavailable

Even worse — some products labelled as “C60” contain no C60 at all, just dyed oil.

✅ How to Identify a Legitimate, High-Quality C60 Product:

🔬 Lab-Tested Purity (Look for 99.95% or higher)
The gold standard is purity above 99.9%, always verified by independent third-party lab testing. Legit brands will show lab reports right on their site.
💧 Properly Dissolved in Oil (Not Just Mixed)
C60 is not water-soluble — it must be fully dissolved in oil, not just suspended.
Look for:
- Cold-pressed, organic olive oil, MCT oil, or avocado oil
- A rich purple-brown tint (if using olive oil)
- No sludge or visible particles at the bottom
🔍 Transparent Branding
Reputable sellers clearly explain:
- Their manufacturing process
- Where the C60 is sourced
- How long it’s stirred and dissolved (typically 2+ weeks in darkness)
🧪 No Added Fillers or Unknown Compounds
The ingredients list should be simple: C60 (purity %), Organic Olive Oil (or MCT, etc.)
⭐ Trusted Reviews and Amazon Seller History
Stick with sellers that:
- Have verified reviews
- Are not brand-new accounts
- Offer clear customer support and return policies

Armed with this information, check out the latest C60 Suppliers on Amazon. As an Amazon associate, I may earn a small commission from any sales generated through these links. At no extra cost to you.

🇺🇸 Buy on Amazon US
🇬🇧 Buy on Amazon UK

🧂 Final Thought: Curious, Not Convinced

I’m not claiming C60 is a miracle or that it’ll double your lifespan. But for me, it’s a low-risk, high-intrigue addition to a lifestyle already built on regeneration and optimization. It’s like a “what if?” experiment I’m running on myself — with eyes wide open.

Feel free to explore, experiment, or just keep an eye on the research. I’ll keep you posted.

📌 Have questions about my supplement stack or C60 experiences? Drop me a message — I’m always happy to share notes with fellow self-experimenters.

FAQ C60 In Olive Oil

What is Carbon 60 (C60)?

Carbon 60 (C60), also known as buckminsterfullerene, is a type of fullerene molecule composed of 60 carbon atoms arranged in a spherical structure resembling a soccer ball. It has a diameter of approximately 1 nanometer. Due to its unique properties, C60 has potential applications in various fields, including cosmetics, medical devices, and medicine.

How can C60 oil affect inflammation?

Studies suggest that C60 may have anti-inflammatory effects. For example, liposoluble C60 in grape seed oil has been shown to inhibit the migration, phagocytosis, and release of TNF-α (a pro-inflammatory cytokine) by human neutrophils, which are key cells involved in inflammatory responses. Another study in rats with chemically induced heart tissue damage found that C60 treatment significantly decreased the expression of COX-2 and TNF-α, both of which are involved in inflammation.

Does C60 oil have antioxidant properties?

Some research indicates that C60 can act as an antioxidant. Liposoluble C60 has demonstrated a scavenging effect on DPPH free radicals in in vitro experiments, a common measure of antioxidant activity. However, other studies suggest that C60 can also induce oxidative stress, particularly when exposed to light.

Can C60 dissolved in Olive Oil affect cardiovascular health?

Research in rats has shown that C60 exposure can have negative impacts on cardiovascular health. Both intratracheal (IT) and intravenous (IV) exposure to C60 were found to exacerbate myocardial infarction following cardiac ischemia/reperfusion injury. Additionally, C60 exposure affected coronary artery function, leading to impaired relaxation and enhanced contraction responses to certain stimuli depending on the route of administration and sex of the rat.

Does the route of C60 oil exposure matter for its effects?

Yes, studies in rats indicate that the route of C60 exposure (intratracheal vs. intravenous) can lead to different biological responses. For instance, intravenous C60 exposure in male rats was associated with impaired acetylcholine relaxation and increased serum levels of certain inflammatory markers, effects not seen with intratracheal exposure. In female rats, intratracheal C60 exposure resulted in larger myocardial infarctions and diminished relaxation responses compared to intravenous exposure.

Can C60 in olive oil induce oxidative stress?

While some studies point to C60’s antioxidant capabilities, other research, particularly in the presence of light or certain conditions, suggests it can induce oxidative stress. Experiments with embryonic zebrafish demonstrated that C60 exposure could elicit oxidative stress responses, affecting the expression of genes related to this pathway. Reducing light exposure or supplementing with antioxidants like N-acetylcysteine attenuated these effects, while inhibiting glutathione synthesis increased sensitivity to C60-induced toxicity.

How does C60 in olive oil influence vascular function?

Studies on isolated coronary arteries from rats and aorta segments from mice have investigated the impact of C60 on vascular function. In rats, C60 exposure affected the arteries’ ability to relax and contract in response to various pharmacological agents. In mice with atherosclerosis, C60 treatment was associated with reduced vasorelaxation responses, suggesting an alteration in the balance of factors regulating blood vessel tone towards vasoconstriction.

What were some specific findings regarding C60 oil’s effects on heart tissue in research studies?

Specific findings from research include:
Liposoluble C60 inhibited neutrophil activity, including migration, phagocytosis, and TNF-α release, at the cellular level.
In rats with DMBA-induced heart tissue damage, C60 treatment reduced oxidative stress markers (MDA) and inflammatory markers (COX-2, TNF-α), while increasing antioxidant enzymes (CAT, GSH) and markers related to cell survival (Caspase-3, p53, HO-1).
In rats subjected to cardiac ischemia/reperfusion injury, both intratracheal and intravenous C60 exposure led to an expansion of myocardial infarction size.
C60 exposure in rats altered the pharmacological responses of isolated coronary arteries, impacting relaxation and contraction depending on the route of administration and sex.
In mice with atherosclerosis, systemic C60 treatment resulted in reduced endothelium-dependent and -independent vasorelaxation responses in aorta segments.

If you enjoyed this article, please consider following me on Facebook and/or Subscribing to my Substack (its free).

📚 References

The information above has been synthesized from a range of scientific studies and expert analyses.

C60 and Lifespan Extension in Rats
Baati, T., et al. (2012). The prolongation of the lifespan of rats by repeated oral administration of [60]fullerene. Biomaterials.
🔗 PubMed
Antioxidant Properties of C60
Andrievsky, G.V., et al. (2013). Possible Mechanisms of Fullerene C60 Antioxidant Action.
🔗 PMC Article
Anti-inflammatory and Antioxidant Effects of Liposoluble C60
Shinohara, N., et al. (2022). Anti-inflammatory and antioxidant effects of liposoluble C60 at the cellular level.
🔗 Tailor & Francis Online
Neuroprotective Potential of Water-Soluble C60 Fullerenes
Shinohara, N., et al. (2015). Cortical and hippocampal EEG interplay in an amyloid-infused rat model treated with water-soluble C60 fullerenes.
🔗 PubMed
C60 Fullerene Reduces Oxidative Stress in Neurodegenerative Models
Shinohara, N., et al. (2021). C60 Fullerene Reduces 3-Nitropropionic Acid-Induced Oxidative Stress in Rats.
🔗 PMC Article
Nrf2 Activation by Polyhydroxylated Fullerene
Shinohara, N., et al. (2014). Polyhydroxylated fullerene attenuates oxidative stress-induced cytotoxicity via Nrf2 activation.
🔗 PMC Article
C60-Based Compounds Inhibit SARS-CoV-2 Spike Protein Interaction
Patino-Alonso, J., et al. (2024). C60-based Multivalent Glycoporphyrins Inhibit SARS-CoV-2 Specific Interaction with the DC-SIGN Transmembrane Receptor.
🔗 PubMed
Interactions of C60 Fullerene with Microplastics and Emerging Contaminants
Williams, T., et al. (2020). Interactions of emerging contaminants with model colloidal microplastics, C60 fullerene, and natural organic matter.
🔗 RSC Publishing
Effects of C60 Fullerene Nanoparticles on Soil Bacteria and Protozoans
Shinohara, N., et al. (2008). Effects of C60 fullerene nanoparticles on soil bacteria and protozoans.
🔗 PubMed
The Rise and Fall of Nanobacteria
Young, E. (2008). The Truth about Nanobacteria. Scientific American.
🔗 Pubmed